Real-World Evidence at Pitt

The University of Pittsburgh and UPMC are leaders in real-world evidence (RWE) generation, providing valuable insights that improve health outcomes and clinical care. Our expert teams of clinicians, data scientists, epidemiologists, and biostatisticians collaborate on diverse RWE projects—from observational studies and comparative effectiveness research to risk stratification and pharmacovigilance. Pitt's broad expertise and established informatics infrastructure, coupled with access to millions of patient records and leading regional and national networks, set us apart as a trusted RWE partner.

Featured Collaborative Research Opportunities
Comparative Effectiveness of Novel Antimicrobial Agents

Study Type: Observational Study | Multisite Study | Comparative Effectiveness

Description: Researchers leveraged the nationwide Precedent Network to compare the clinical efficacy of novel antibiotics for treating multidrug-resistant Pseudomonas aeruginosa infections. The study included molecular characterization and susceptibility testing of bacterial isolates across multiple medical centers, providing real-world evidence on treatment effectiveness.

Ideal Partner Profile: Pharmaceutical and biotech companies developing antimicrobial agents, seeking comparative effectiveness data to support regulatory submissions or post-market surveillance.

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Population-Level Risk Stratification for NASH

Study Type: Observational Study | Multisite Study | Risk Stratification

Description: Using the PaTH Network and PCORnet member sites, researchers analyzed approximately 12 million patient records to test a population-level risk stratification strategy using noninvasive tests of liver fibrosis. The study identified barriers to screening strategies and informed alternative approaches for identifying at-risk populations.

Ideal Partner Profile: Pharmaceutical companies developing NASH therapies, diagnostics companies, and health systems seeking population health management strategies.

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Featured Collaborative Research Opportunities

UPMC Annual Patient Activity:

Our established informatics infrastructure provides access to:

  • Electronic health records (EHR)
  • Claims data
  • Clinical registries
  • Patient-reported outcomes
  • Genomic and biomarker data
6.2M
Outpatient Visits
1M
Emergency Visits
340K
Inpatient Admissions
250K
Surgeries
Research Networks & Centers
Trilogue Center for Real-World Evidence

Department of Medicine-led center that expands and accelerates research in collaboration with industry partners. Robust collaboration between clinical researchers and informaticians provides access to diverse data sources, study designs, and multidisciplinary teams.

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PaTH Network

A PCORnet® partner and national Patient-Centered Clinical Research Network that enables multisite patient-centered research across multiple health systems. Provides access to high-quality health data, patient partnership, and deep research experience.

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Precedent Network

Consortium of leading medical centers focused on real-world effectiveness of antimicrobial agents and treatment pathways for patients infected by multidrug-resistant pathogens. Conducts comparative effectiveness studies with centralized microbiologic testing and whole-genome sequencing.

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Partner with Pitt on RWE

Our Capabilities Span the Full RWE Spectrum:

Analyzing EHR data, claims data, and survey data using prospective and retrospective approaches

Evaluating and comparing health outcomes, clinical effectiveness, risks, and benefits of different treatments

Leveraging networks spanning multiple healthcare systems for larger, more diverse populations

Identifying patients with specific diseases or conditions for targeted interventions

Building and managing disease-specific or treatment-specific patient cohorts

Testing interventions in real-world clinical settings

Monitoring drug safety and adverse events in real-world populations

Assessing cost-effectiveness and value of treatments

Developing tools to predict patient outcomes and guide clinical decisions

Resources & Next Steps
Find Faculty Expertise

Connect with our clinicians, epidemiologists, biostatisticians, and data scientists leading real-world evidence research.

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Explore Available Technologies

Browse our portfolio of RWE tools, methodologies, and licensable innovations.

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Start a Conversation

Ready to discuss your RWE needs? Our team can help design studies that generate the evidence you need.

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Let's Design Your Real-World Evidence Study

Whether you need observational data, comparative effectiveness research, or multisite collaboration, our Industry Partnerships team can connect you with the right expertise and resources.

Office of Innovation and Entrepreneurship
partner@pitt.edu